Proline Protects Boar Sperm against Oxidative Stress through Proline Dehydrogenase-Mediated Metabolism and the Amine Structure of Pyrrolidine
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چکیده
منابع مشابه
Proline metabolism and microenvironmental stress.
Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of enzymes responding to metabolic stress and participating in metabolic signaling. Collagen in extracellular matrix, connective tissue, and bone is an abundant reservoir for proline. Matrix metalloproteinases degrading collagen are activated during stress to make proline available, and proline oxidase, the f...
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The effect of various NaCl treatments (0, 50, 100, 200 and 300 mM) at different growth and development stages (tillering, boot swelling, flowering and polination) of two wheat cultivars (Ghods : salt-sensitive; Boolani : salt-resistant) on proline concentration and the kinetic activity of proline dehydrogenase was studied under greenhouse conditions. Generally, in response to salinity treatment...
متن کاملRole of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress.
Flavoproteins catalyze a variety of reactions utilizing flavin mononucleotide or flavin adenine dinucleotide as cofactors. The oxidoreductase properties of flavoenzymes implicate them in redox homeostasis, oxidative stress, and various cellular processes, including programmed cell death. Here we explore three critical flavoproteins involved in apoptosis and redox signaling, ie, apoptosis-induci...
متن کاملStructure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus.
Proline dehydrogenase (PRODH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) catalyze the two-step oxidation of proline to glutamate. They are distinct monofunctional enzymes in all eukaryotes and some bacteria but are fused into bifunctional enzymes known as proline utilization A (PutA) in other bacteria. Here we report the first structure and biochemical data for a monofunctional ...
متن کاملProline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death.
Proline metabolism has an underlying role in apoptotic signaling that influences tumorigenesis. Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH). PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis. Paradoxical to its role in apoptos...
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ژورنال
عنوان ژورنال: Animals
سال: 2020
ISSN: 2076-2615
DOI: 10.3390/ani10091549